Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Influenza Virus Host Resistance in Mice
Identifieur interne : 001C33 ( Main/Exploration ); précédent : 001C32; suivant : 001C34Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Influenza Virus Host Resistance in Mice
Auteurs : Gary R. Burleson [États-Unis] ; Hervè Lebrec [États-Unis] ; Yung G. Yang [États-Unis] ; Joelle D. Ibanes [États-Unis] ; Kevin N. Pennington [États-Unis] ; Linda S. Birnbaum [États-Unis]Source :
- Toxicological Sciences [ 1096-6080 ] ; 1996.
Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes numerous immunotoxic effects including thymic involution and an immunosuppression of nonspecific as well as specific cell- and humoralmediated immunity. TCDD administration to laboratory animals also results in a decreased resistance to numerous bacteria, viruses, and parasites. Effects on virus host resistance appear to be among the most sensitive effects of TCDD immunotoxicity. However, previous studies have not achieved a no effect level. The present studies utilized an influenza virus host resistance model in mice to quantify the sensitivity of this model to TCDD and to determine the NOAEL (no observed adverse effect level) of TCDD for influenza virus. Results indicated that a single dose of TCDD at 0.10, 0.05, or 0.01 μg/kg resulted in an increased mortality to Hong Kong influenza virus when mice were challenged 7 days after TCDD administration. Increased mortality was not correlated with increased virus titers in the lungs. TCDD at 0.005 or 0.001 μg/kg had no effect on influenza-induced mortality. TCDD alone did not affect thymus weight at any dose administered in this study. TCDD also did not alter the virus-enhanced increase in lung weight:body weight ratio nor the virus-induced decrease in thymus weight. Thus, low levels of TCDD exposure lead to enhanced mortality to influenza virus; however, the mechanism of this effect remains to be elucidated. Nonetheless, enhanced mortality to influenza virus in mice following a single dose of 10 ng TCDD/kg represents the most sensitive adverse effect yet reported for TCDD.
Url:
DOI: 10.1093/toxsci/29.1.40
Affiliations:
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Burleson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>U.S. Environmental Protection Agency, Health Effects Research Laboratory Research Triangle Park</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>To whom correspondence should be addressed at present address: The Procter & Gamble Co., Miami Valley Laboratories, P.O. Box 398707, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>2 To whom correspondence should be addressed at present address: The Procter & Gamble Co., Miami Valley Laboratories, P.O. Box 398707, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Lebrec, Herve" sort="Lebrec, Herve" uniqKey="Lebrec H" first="Hervè" last="Lebrec">Hervè Lebrec</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>U.S. Environmental Protection Agency, Health Effects Research Laboratory Research Triangle Park</wicri:cityArea></affiliation></author><author><name sortKey="Yang, Yung G" sort="Yang, Yung G" uniqKey="Yang Y" first="Yung G." last="Yang">Yung G. 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Birnbaum</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>U.S. Environmental Protection Agency, Health Effects Research Laboratory Research Triangle Park</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Toxicological Sciences</title><idno type="eISSN">1096-0929</idno><idno type="ISSN">1096-6080</idno><imprint><publisher>Oxford University Press</publisher><date when="1996-01">1996</date><biblScope unit="vol">29</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="40">40</biblScope><biblScope unit="page" to="47">47</biblScope></imprint><idno type="ISSN">1096-6080</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1096-6080</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes numerous immunotoxic effects including thymic involution and an immunosuppression of nonspecific as well as specific cell- and humoralmediated immunity. TCDD administration to laboratory animals also results in a decreased resistance to numerous bacteria, viruses, and parasites. Effects on virus host resistance appear to be among the most sensitive effects of TCDD immunotoxicity. However, previous studies have not achieved a no effect level. The present studies utilized an influenza virus host resistance model in mice to quantify the sensitivity of this model to TCDD and to determine the NOAEL (no observed adverse effect level) of TCDD for influenza virus. Results indicated that a single dose of TCDD at 0.10, 0.05, or 0.01 μg/kg resulted in an increased mortality to Hong Kong influenza virus when mice were challenged 7 days after TCDD administration. Increased mortality was not correlated with increased virus titers in the lungs. TCDD at 0.005 or 0.001 μg/kg had no effect on influenza-induced mortality. TCDD alone did not affect thymus weight at any dose administered in this study. TCDD also did not alter the virus-enhanced increase in lung weight:body weight ratio nor the virus-induced decrease in thymus weight. Thus, low levels of TCDD exposure lead to enhanced mortality to influenza virus; however, the mechanism of this effect remains to be elucidated. Nonetheless, enhanced mortality to influenza virus in mice following a single dose of 10 ng TCDD/kg represents the most sensitive adverse effect yet reported for TCDD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Burleson, Gary R" sort="Burleson, Gary R" uniqKey="Burleson G" first="Gary R." last="Burleson">Gary R. Burleson</name></region><name sortKey="Birnbaum, Linda S" sort="Birnbaum, Linda S" uniqKey="Birnbaum L" first="Linda S." last="Birnbaum">Linda S. Birnbaum</name><name sortKey="Burleson, Gary R" sort="Burleson, Gary R" uniqKey="Burleson G" first="Gary R." last="Burleson">Gary R. Burleson</name><name sortKey="Burleson, Gary R" sort="Burleson, Gary R" uniqKey="Burleson G" first="Gary R." last="Burleson">Gary R. Burleson</name><name sortKey="Ibanes, Joelle D" sort="Ibanes, Joelle D" uniqKey="Ibanes J" first="Joelle D." last="Ibanes">Joelle D. Ibanes</name><name sortKey="Lebrec, Herve" sort="Lebrec, Herve" uniqKey="Lebrec H" first="Hervè" last="Lebrec">Hervè Lebrec</name><name sortKey="Pennington, Kevin N" sort="Pennington, Kevin N" uniqKey="Pennington K" first="Kevin N." last="Pennington">Kevin N. Pennington</name><name sortKey="Yang, Yung G" sort="Yang, Yung G" uniqKey="Yang Y" first="Yung G." last="Yang">Yung G. Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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